2005-12-11 20:13:58 UTC
PermalinkIm busy with a new synthesis for the Meth & Amphetamine precursor
Phenyl-2-Propanone / Methyl Benzyl Ketone. Recently I found out that ( some
? ) Paint-Thinner
contains 2 ingredients:
Toluene or Methyl Benzene
On Rhodium Drug Archive there is a synthesis using Ethyl acetate and
Benzylcyanide in the P-2-P section.
This Reaction is very intresting for a new synthesis using Toluene and Ethyl
acetate. First look at the original
1 Benzyl Cyanide + Ethyl Acetate + Sodium Ethoxide =
2 Alpha-PhenylAcetoacetonitrile + H2SO4 = Phenylacetone
What will happen in the reaction in practice is that in the first step a
crystaline mass is produced and this is acidfied
with acetic acid in h20 to seperate the Alpha-PhenylAcetoAcetonitrile out
from the crystals.
In my own experiment with Toluene instead of Bezyl Cyanide the crystaline
mass is produced. I dissolve these cristals
in 8% Acetic acid , but no Phenyl-2-Acetone will form, Why Why Why ?
Ph-CH3 + CH3COOCH2CH3 + Strong Base = PhCH2COCH3 + OHCH2CH3 or what ?
Is 8% Acetic Acid not strong enough ?
any help with this project or what,
THANKS FOR THE SUPPORT